Facial Expression Wrinkles and Their Relaxation by a Synthetic Peptide
The author:佚名    Released in:2021年04月26日
摘要:the peptide diaminobutyroyl benzylamide diacetate helps smoothen facial expression wrinkles, and thus counteracts visible signs of aging

Expression wrinkles form over time due to repeated facial movements such as smiling and frowning. They have an imprint on facial skin in areas such as the corner of the eyes, where they take the form of crow’s feet, the forehead and the glabella, where they appear as frown lines, and around the mouth, as marionette lines. In the study presented here, we recruited two sets of volunteers. 

Mimic Wrinkle Patterns in Daughters’ Expressive Faces Resemble Patterns in Mothers’ Relaxed Faces

Facial Expression Wrinkles and Their Relaxation by a Synthetic Peptide

Resemblance of daughters and mothers. a Side view of biological mother–daughter pairs participating in the study. They clearly look alike. b) Frown lines on the glabella of the daughters’ angry face look similar to the ones on the mother’s relaxed face. Frown lines 1 and 2 form in the daughter when she pulls an angry face and are extended at the same place on the mothers’ relaxed face. The lower panel shows a wrinkle enhancement highlighting the wrinkles present in the standard images of the upper panel. c Crows’ feet on the edge of the eye of the daughters’ smiling face look similar to the ones on the mother’s relaxed face. Crows’ feet 1, 2, 3, and 4 form in the daughter when she smiles and are extended at the same place on the mothers’ relaxed face. The lower panel shows a wrinkle enhancement highlighting the wrinkles present in the standard images of the upper panel

DABBA can Smoothen Persistent Facial Mimic Wrinkles

Facial Expression Wrinkles and Their Relaxation by a Synthetic Peptide

Expert Grading of Facial Wrinkles in ‘Mothers’ Shows a Wrinkle Decrease After 4 weeks of DABBA Use

Facial Expression Wrinkles and Their Relaxation by a Synthetic Peptide

Facial color map of changes in visible wrinkles as assessed by expert grading for the group using the DABBA formulation. Front and side view are shown. The corresponding color map is displayed on the right. The more intense the color, the greater the improvement in wrinkle severity


In conclusion, by using a mother-daughter comparison of expressed and relaxed faces, we have shown how expression wrinkles imprint facial skin. We provide further evidence using different methodologies that the peptide diaminobutyroyl benzylamide diacetate helps smoothen facial expression wrinkles, and thus counteracts visible signs of aging. In addition, we present a novel facial colour map based on expert grading for augmented visualization of anti-wrinkle treatments.


Original source:

Campiche, R., Pascucci, F., Jiang, L. et al. Facial Expression Wrinkles and Their Relaxation by a Synthetic Peptide. Int J Pept Res Ther 27, 1009–1017 (2021). https://doi.org/10.1007/s10989-020-10146-z


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