Cosmetic peptide µ-Conotoxin is a good Anti-wrinkle products
The author:Go Top Peptide Biotech    Released in:2021年05月10日
摘要:Cosmetic peptide µ-Conotoxin is a good Anti-wrinkle products

µ-Conotoxin GIIIB was originally isolated from the marine snail Conus geographus. The peptide toxin selectively blocks NaV1.4 channels, which are expressed predominantly in skeletal muscle. It is a potent blocker and 600 nM completely blocked NaV1.4-related currents in rat skeletal muscle.


  • Cosmetic peptide µ-Conotoxin is a good Anti-wrinkle products


Cosmetic peptide µ-Conotoxin is a good Anti-wrinkle productsEDL muscle fibers from SBMA mice show reduced sensitivity to µ-Conotoxin GIIIB.Traces of action potentials before and after incubation in 2.5 µM µ-Conotoxin GIIIB (#C-270) for 30 minutes. Potentials were blocked in WT fibers (left) but not in diseased fibers (right).Adapted from Xu, Y. et al. (2016) J. Neurosci. 36, 5094. with permission of The Society for Neuroscience.

Our bioassay

  • Cosmetic peptide µ-Conotoxin is a good Anti-wrinkle products

    Alomone Labs μ-Conotoxin GIIIB inhibits NaV1.4 channels heterologously expressed in Xenopus oocytes.

    100 nM μ-Conotoxin GIIIB (#C-270) inhibited Nacurrents. Holding potential was -100 mV and test pulses of 25 ms to -20 mV were delivered every 5 sec. Left: Time course of current inhibition by toxin and recovery. The bar represents period of toxin perfusion. Right: Superimposed traces of NaV1.4 current before (black) and during (orange) application of μ-Conotoxin GIIIB.




Cosmetic peptide µ-Conotoxin is a good Anti-wrinkle products

Hangzhou Go Top Peptide Biotech is a technology-based peptide company and National High-tech Enterprise located in Hangzhou, China. And has an experienced scientific research team that can provide customers with high-quality products and professional services.Main service include Custom peptide synthesis, Peptide CRO/CDMO,Non-GMP and GMP peptide, Cosmetic peptide. For any requests of Peptide for research purpose,welcome to contact us.  www.gtpeptide.com,  sales3@gotopbio.com.

Tel: +86-571-88211951 , 88211921. Fax:+86-571-88211907
Email: sales@gotopbio.com, Sales1@gotopbio.com
Add: Room 501, Building 1, No. 600, Yinhai Street, Qiantang New District, Hangzhou 310018, Zhejiang, P.R.China. 浙ICP备18017542号-1