Special carnosine molecules may prevent damaging cell changes induced by type 2 diabetes and obesity
The author:Go Top Peptide Biotech    Released in:2021年11月01日
摘要:Scientists from Nottingham Trent University and other institutions have discovered through research that the large number of damaging chemical changes in the bodys cells caused by diabetes and obesity may be expected to be prevented by a naturally occurring molecule.

Scientists from Nottingham Trent University and other institutions have discovered through research that the large number of damaging chemical changes in the body's cells caused by diabetes and obesity may be expected to be prevented by a naturally occurring molecule.

The main feature of type 2 diabetes is that the body cannot effectively control the balance of glucose. Because the body cells and tissues are exposed to high concentrations of glucose and fatty acids for a long time, the body will have a variety of complications of diabetes. This is partly due to advanced glycation and The formation of advanced lipidation end products can help modify the structure of proteins, lipids or DNA and disrupt normal cell functions. Recently, a research report entitled "Carnosine protects stimulus-secretion coupling through prevention of protein carbonyl adduction events in cells under metabolic stress" was published in the international journal Free Radical Biology and Medicine, from Nottingham Trent University and other institutions Scientists have discovered through research that a large number of damaging chemical changes in body cells caused by diabetes and obesity may be expected to be prevented by a naturally occurring molecule.

Special carnosine molecules may prevent damaging cell changes induced by type 2 diabetes and obesity

In type 2 diabetes, when glucose stays in the blood, it may not be used as a dye needed to produce energy, but will lead to the formation of toxic molecules. In the article, the researchers analyzed the effects of a molecule called carnosine, which is a molecule that exists in human skeletal muscle. It can be obtained by ingesting fish and meat and can be As a nutritional supplement. Although this requires further research, it may help scientists develop new drugs related to carnosine to help solve the previously unresolved aspect of type 2 diabetes.

In the article, the researchers used mass spectrometry (the process of weighing and separating molecules) to identify protein molecules in the patient's blood that were damaged by increased glucose and fat levels. By comparing the blood of healthy individuals, researchers can identify disease-related changes in patients with obesity, type 2 diabetes, and gestational diabetes. After further research, they investigated the extent to which carnosine can prevent similar destructive protein modifications in cells and tissues related to glucose control; the researchers found that carnosine can prevent 65% to 90% of destructive chemical changes and can Protect the functional properties of the affected cells; although the cells are damaged, carnosine can protect the function of the cells by absorption toxicity analysis.

Previously, researchers revealed the potential of carnosine in controlling the body's blood sugar levels, but now they understand which protein is being destroyed. Dr. Mark Turner pointed out that the regulation of blood sugar is vital to the human body, which can help ensure that vital organs’ energy needs are met. In the body of type 2 diabetic patients, certain molecules become no longer effective, and when it comes to regulating the body's glucose levels, it may not be able to do its job normally. After identifying these molecules in the patient group, the researchers wanted to analyze the key role carnosine plays in preventing its damage.

The researchers found that carnosine can protect the cells responsible for controlling the body's blood sugar levels, which increases sensitivity to glucose and leads to more insulin release; although this requires further research, this research confirms the researchers The hypothesis that carnosine may provide important therapeutic potential in fighting type 2 diabetes; type 2 diabetes is usually related to overweight, inactivity and family history, which is a lifelong cause of high blood glucose levels in the body. disease. This condition occurs when the pancreas cannot release enough insulin or the body's cells do not respond to insulin.

Special carnosine molecules may prevent damaging cell changes induced by type 2 diabetes and obesity

In recent years, the incidence of type 2 diabetes has been increasing at an alarming rate. It is expected to increase from 450 million people worldwide in 2017 to 693 million in 2045. In summary, the results of this article show that carnosine may provide an important therapeutic measure against human metabolic diseases.


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