Biologists discover new protein folding drivers
The author:Go Top Peptide Biotech    Released in:2021年11月05日
摘要:Recently, a research team from the University of Pennsylvania in the United States discovered that a new type of protein folding driving factor DAXX (DeathDomain-associated Protein, DAXX) can reasonably control the proper folding of proteins. To The relevant research is published in Nature under the title: DAXXrepresentsanewtypeofprotein-foldingenabler.

Recently, a research team from the University of Pennsylvania in the United States discovered that a new type of protein folding driving factor DAXX (DeathDomain-associated Protein, DAXX) can reasonably control the proper folding of proteins. To

The relevant research is published in "Nature" under the title: DAXXrepresentsanewtypeofprotein-foldingenabler.

Biologists discover new protein folding drivers

The structure of protein decision-making and its role. To

Protein folding is the whole process of obtaining a multifunctional structure of a protein. According to this whole process of physics, the protein folds into a specific multifunctional three-dimensional structure from irregular rolling conditions. To

Researchers found that the DAXX protein can not only inhibit the aggregation of misfolded proteins, but also dissolve aggregated proteins. To

The DAXX protein can also help the misfolded protein recover its structure and perform its function. The substrate protein of DAXX protein includes a variety of important proteins for neurodegenerative diseases and its tumor suppressor factors p53. To

Further research also found that DAXX protein is not the same as its molecular chaperone (the effect is to help the protein to fold properly), and it does not necessarily provide energy when it is fully functional. The results of this study show that the DXAA protein is a new type of protein folding driving factor and a key member of the "protein quality control system" in the cell.


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