PNC27 peptide,PNC27
Product introduction

Product Name:PNC27 peptide

Synonyms:PNC27

CAS No.:

Catalog No.:GT-M026

Sequence:H-Pro-Pro-Leu-Ser-Gln-Glu-Thr-Phe-Ser-Asp-Leu-Trp-Lys-Leu-Leu-Lys-Lys-Trp-Lys-Met-Arg-Arg-Asn-Gln-Phe-Trp-Val-Lys-Val-Gln-Arg-Gly-OH

Molecular Formula:C188H293N53O44S

Molecular Weight:4032.13

 

PNC27 peptide  chemical formula diagram

Key Specification:

Appearance: White powder
Purity(HPLC): ≥98.0%
Single Impurity(HPLC): ≤1.0%
Acetate Content(HPLC): 5.0%~12.0%
Water Content (Karl Fischer): ≤10.0%

Package: 500mg,1g, 5g, 10g, 20g, 50g, 100g, 200g, 500g

 

Description:

PNC-27 is a membrane active peptide that binds to the HDM-2 protein expressed in the cancer cell membrane of solid tissue tumor cells, and induces the formation of transmembrane pores in cancer rather than normal cells, leading to independent tumor cell necrosis Changes in p53 activity in these cells.

 

PNC-27 contains amino acid residues 12-26 of the p53 protein of its HDM-2 binding domain, which are connected to a transmembrane penetration sequence, also known as membrane resident peptide (MRP). PNC-27 and PNC-28 (its sequence is the same as PNC-27, but lacks the first six amino acid residues of PNC-27 (ie p53 residues 17-26)) for a variety of IC50 values ranging from 75 ug/ml ( 18.6 uM) to 200 ug/ml (50 uM) cancer cells; on the other hand, any peptide will not affect normal or untransformed cells in culture, including the highest hematopoietic stem cells. The latter findings indicate that, contrary to the effects of many chemotherapeutics, these two peptides are not toxic to bone marrow function.

 

Storage:Cool dry place( Store at -20°C, away from the light)

Remark:For Research Use Only. Not for human use. 

PNC27 peptide product picturePNC27 peptide  Raw material map



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