Description

Glatiramer acetate is a synthetic analog and immunomodulator of myelin basic protein, used to treat multiple sclerosis. Glatiramer acetate shows a strong and heterogeneous binding to MHC molecules, thereby competing with various myelin antigens for presentation to T cells. Another aspect of the action of glatiramer acetate is its effectiveness in inducing specific T helper cell type 2 suppression, leading to the migration of these cells to the brain and resulting in in situ bystander suppression.

Specifications

Apperance: White to off-white powder

Purity(HPLC): ≥98.0%

Single Impurity: ≤2.0%

Acetate Content(HPLC): 5.0%～12.0%

Water Content (Karl Fischer): ≤10.0%

Peptide Content: ≥80.0%

Packing and Shipping: Low temperature, vacuum packing, accurate to mg as required.

FAQ：

Which modified labeled polypeptides can be synthesized in Chinese peptide?

Our company provides a variety of modified peptide labeling, such as acetylation, biotin labeling, phosphorylation modification, fluorescence modification, can also be customized according to your special needs.

What is net weight? What is peptide content?

After lyophilized peptide is generally fluffy and fluff-like, it may still contain trace amounts of water, adsorbed solvents and salts due to the characteristics of peptide itself. This does not mean that the purity of the peptide is not enough, but that the actual content of the peptide is reduced by 10% to 30%. The net weight of the peptide is the actual weight of the peptide minus the water and protonated ions. In order to ensure the concentration of peptide, the non-peptide substances need to be removed from the crude peptide.

Why should peptides be modified by N-terminal acetylation and C-terminal amidation?
Such modifications can give peptide sequences properties that are native to proteins.

If you want to do a biotin modification at the N terminal, do you need to put a gap between the biotin and the peptide sequence?

The standard biotin labeling procedure used by our company is to attach an Ahx to the peptide chain, followed by biotin. Ahx is a 6-carbon compound that acts as a barrier between the peptide and the biotin.

How is the solubility of peptides? 

The solubility of peptides is influenced by various factors, including amino acid sequence, charge, hydrophilicity and hydrophobicity, etc. When dissolving peptides, it is recommended to conduct a small-scale solubility test first, and after confirming complete dissolution, proceed with dilution. Go top bio provides solubility testing services.