LL-37 supplier/597562-32-8/Peptide raw materials

Description

LL-37 is a member of antimicrobial peptides and one of the peptides produced autonomously by the human body. It is an antimicrobial peptide derived from a 37-residue amphipathic tissue protein, possessing broad-spectrum antibacterial activity. LL-37 helps protect the cornea from infection, regulates wound healing, and exhibits antimicrobial and anti-biofilm activity against a variety of Gram-positive and Gram-negative human pathogens, while also promoting wound healing in the host.

Specifications

Apperance: White to off-white powder

Purity(HPLC): ≥98.0%

Single Impurity: ≤2.0%

Acetate Content(HPLC): 5.0%～12.0%

Water Content (Karl Fischer): ≤10.0%

Peptide Content: ≥80.0%

Packing and Shipping: Low temperature, vacuum packing, accurate to mg as required.

FAQ：

How is my peptide transported? What test reports are provided?

All freeze-dried polypeptides are usually stored in special containers of 2 ml or 10ml with original analytical data and synthesis reports containing important information such as sequence, molecular weight, purity, weight, and number of the polypeptide.

What are peptides?

Peptides are short chain molecules formed by amino acids linked together by peptide bonds. They typically consist of 2 to 70 amino acids.

What is the role of peptides in skincare products? 

Peptides have various functions in skincare products, including:

Moisturizing: Peptides can help the skin retain moisture and increase skin hydration.

Anti-aging: Peptides can stimulate collagen production, reduce wrinkles, and improve skin elasticity.

Whitening: Some peptides can inhibit melanin production and lighten spots.

Repair: Peptides can promote cell metabolism and help repair damaged skin.

Were the peptides containing Cys reduced before shipment?

If the peptide is not found to have been oxidized, we generally do not reduce Cys. All polypeptides are obtained from crude products purified and lyophilized under pH2 conditions, which at least to some extent prevent the oxidation of Cys. Peptides containing Cys are purified at pH2 unless there is a specific reason to purify at pH6.8. If purification is performed at pH6.8, the purified product must be treated with acid immediately to prevent oxidation. In the final quality control step, for the peptides containing Cys, if the presence of molecular weight (2P+H) substance is found on the MS map, it indicates that a dimer has been formed. If there is no problem with MS and HPLC, we will directly lyophilize and ship the goods without any further processing. It should be noted that peptides containing Cys undergo slow oxidation over time, and the degree of oxidation depends on peptide sequence and storage conditions.

What is the direction of synthesis of peptides?
Peptide synthesis is from the C-terminus to the N-terminus of the polypeptide.