Ranalexin supplier/155761-99-2/Peptide synthesis

Ranalexin is an antibacterial peptide extracted from the skin of bullfrogs. It can resist external microorganisms and eliminate parasites. It has strong antibacterial activity against Gram-negative bacteria and fungi. It is a very important defense system in the body. It consists of 20 amino acids and has a stable disulfide bond cyclic space structure.

Specifications

Apperance: White to off-white powder

Purity(HPLC): ≥98.0%

Single Impurity: ≤2.0%

Acetate Content(HPLC): 5.0%～12.0%

Water Content (Karl Fischer): ≤10.0%

Peptide Content: ≥80.0%

Packing and Shipping: Low temperature, vacuum packing, accurate to mg as required.

FAQ：

How to choose the salt form of peptides?

The choice of the salt form of peptides needs to consider various factors, including the peptide sequence, stability, solubility, biotoxicity, and specific experimental requirements. By default, peptides are generally delivered as trifluoroacetic acid (TFA) salts; in addition, peptides can also exist in forms such as acetate, ammonium, and sodium salts.

What are small molecular peptides?

Peptides are formed by multiple amino acids connected through peptide bonds. The difference from proteins is the number of amino acids that make up the molecule. Oligopeptides, consisting of 2-9 amino acids, are also known as small molecular peptides, with an average molecular weight of amino acids being 128 Da. Therefore, the molecular weight of oligopeptides is generally less than 1000 Da.

What are the advantages of Pharmaceutical Peptide?
The rapid development of Pharmaceutical Peptide benefits from their significant advantages:

• Significant activity, relatively strong specificity, good affinity for receptors, lower toxicity, and not easily accumulating in the body;

• Compared to protein-based macromolecular drugs, except for peptide vaccines, peptide drugs have relatively low immunogenicity, require smaller dosages, and have higher unit activity;

• Easy to modify and produce, and can even be addressed through synthetic methods.

I need a cyclic peptide, which contains a tryptophan, will it be oxidized?

The oxidation of tryptophan is a common phenomenon in peptide oxidation, and peptides are usually cyclized before purification. If the oxidation of tryptophan occurs, the retention time of the peptide on the HPLC column will change, and the oxidation can be removed by purification. Furthermore, oxidized peptides can also be detected by MS.

What are the differences between peptides and proteins?

Peptides and proteins are both composed of amino acids, but they differ in molecular weight and length. Generally, those with a molecular weight less than 10,000 daltons (Da) and shorter amino acid chains are called peptides, while those with a larger molecular weight and longer amino acid chains are referred to as proteins.