Thymogen supplier/122933-59-9/Peptide supplier

Thymogen is a dipeptide immunomodulator isolated from calf thymus, which can inhibit vascular endothelial growth factor (VEGF). Thymogen can stimulate the immune response against hepatitis C virus and intracellular bacterial infections. Thymogen has anti-tumor and anti-angiogenesis activities.

Specifications

Apperance: White to off-white powder

Purity(HPLC): ≥98.0%

Single Impurity: ≤2.0%

Acetate Content(HPLC): 5.0%～12.0%

Water Content (Karl Fischer): ≤10.0%

Peptide Content: ≥80.0%

Packing and Shipping: Low temperature, vacuum packing, accurate to mg as required.

FAQ：

What is the direction of synthesis of peptides?
Peptide synthesis is from the C-terminus to the N-terminus of the polypeptide.

What length of peptide is appropriate?
Peptide synthesis needs to consider factors such as the length, charge, and hydrophilicity of the peptide. The longer the length, the purity and yield of the crude synthetic product decrease, and the difficulty of purification and the chance of non-synthesis will be greater. Of course, the sequence of the functional region of the polypeptide cannot be changed, but for the smooth synthesis of the polypeptide, sometimes some auxiliary amino acids have to be added to the upstream and downstream of the functional take to improve the solubility and hydrophilicity of the polypeptide. If the polypeptide is too short, there may also be problems with synthesis, the main problem is that the synthetic polypeptide has a certain difficulty in the post-processing process, and the polypeptide below 5 peptides generally has hydrophobic amino acids, otherwise the post-processing is more difficult. Peptides below 15 amino acid residues generally have satisfactory yields and yields.

Which modified labeled polypeptides can be synthesized in Chinese peptide?

Our company provides a variety of modified peptide labeling, such as acetylation, biotin labeling, phosphorylation modification, fluorescence modification, can also be customized according to your special needs.

What are the best preservation conditions? How stable is the peptide?

After lyophilized, polypeptide can form fluff or flocculant powder, which can avoid premature degradation of polypeptide. Recommended storage conditions: a. -20℃ storage or dry environment b. Try to avoid repeated freeze-thaw c. Try to avoid storage in solution state (freeze-dried powder can be stored in separate packages for convenience of use) d. If it must be stored in solution, it is recommended to dissolve the peptides in sterile water under weakly acidic conditions and store at -20℃.

How do you dissolve polypeptides?

The solubility of polypeptide depends mainly on its primary and secondary structure, the nature of modification label, solvent type and final concentration. If the peptide is insoluble in water, ultrasound can help dissolve it. For basic peptide, it is recommended to dissolve with 10% acetic acid; For acidic peptides, dissolution with 10%NH4HCO3 is recommended. Organic solvents can also be added to insoluble polypeptides. The peptide is dissolved in the least amount of organic solvent (e.g., DMSO, DMF, isopropyl alcohol, methanol, etc.). It is highly recommended that the peptide be dissolved in the organic solvent first and then slowly added to water or other buffer until the desired concentration.