Tripeptide-29 supplier/2239-67-0/Peptide detection

Description

Tripeptide-29 is a synthetic peptide composed of three amino acids: glycine, proline, and hydroxyproline. It's known for its ability to stimulate collagen production, potentially reducing the appearance of fine lines and wrinkles and improving skin elasticity. Due to its small size, it can penetrate the skin's upper layers more effectively.

Specifications

Apperance: White to off-white powder

Purity(HPLC): ≥98.0%

Single Impurity: ≤2.0%

Acetate Content(HPLC): 5.0%～12.0%

Water Content (Karl Fischer): ≤10.0%

Peptide Content: ≥80.0%

Packing and Shipping: Low temperature, vacuum packing, accurate to mg as required.

FAQ：

Were the peptides containing Cys reduced before shipment?

If the peptide is not found to have been oxidized, we generally do not reduce Cys. All polypeptides are obtained from crude products purified and lyophilized under pH2 conditions, which at least to some extent prevent the oxidation of Cys. Peptides containing Cys are purified at pH2 unless there is a specific reason to purify at pH6.8. If purification is performed at pH6.8, the purified product must be treated with acid immediately to prevent oxidation. In the final quality control step, for the peptides containing Cys, if the presence of molecular weight (2P+H) substance is found on the MS map, it indicates that a dimer has been formed. If there is no problem with MS and HPLC, we will directly lyophilize and ship the goods without any further processing. It should be noted that peptides containing Cys undergo slow oxidation over time, and the degree of oxidation depends on peptide sequence and storage conditions.

Which modified labeled polypeptides can be synthesized in Chinese peptide?

Our company provides a variety of modified peptide labeling, such as acetylation, biotin labeling, phosphorylation modification, fluorescence modification, can also be customized according to your special needs.

What is net weight? What is peptide content?

After lyophilized peptide is generally fluffy and fluff-like, it may still contain trace amounts of water, adsorbed solvents and salts due to the characteristics of peptide itself. This does not mean that the purity of the peptide is not enough, but that the actual content of the peptide is reduced by 10% to 30%. The net weight of the peptide is the actual weight of the peptide minus the water and protonated ions. In order to ensure the concentration of peptide, the non-peptide substances need to be removed from the crude peptide.

What are the advantages of PEG-modified peptides?
Polyethylene glycol modification is the addition of a polymer (ethylene glycol) to the target molecule by means of covalent bonding. By camouflaging the peptide, the PEG modification fools the host cell's immune system, enhances the therapeutic effect of the peptide, and increases the solubility and bioavailability of the hydrophobic drug. It can also prolong the circulation time of polypeptides by decreasing renal clearance.

What are peptides?

Peptides are short chain molecules formed by amino acids linked together by peptide bonds. They typically consist of 2 to 70 amino acids.