Abareric acid is composed of ten amino acids. It can directly inhibit the metabolism of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), thereby reducing the formation of testosterone in the testes. Due to its direct inhibition of LH secretion, the blood testosterone concentration does not rise and then drop. The results show that abareric acid has a high affinity for the LHRH receptor in the rat pituitary gland.
Purpose
Abareric acid acetate is not suitable for treatment with LHRH agonists and is not amenable to surgical removal. For advanced symptomatic prostate cancer with one or more of the following conditions (PCA) for palliative treatment:
(1) Tumor metastasis may cause nerve damage;
(2) The urethral tube or bladder outlet may be blocked due to local injury or metastasis;
(3) Severe bone pain caused by tumor bone metastasis requires reliance on anesthetic analgesics.
Basic information: 醋酸阿巴瑞克
English name: Abarelix Acetate
Product Number: GT-F007
CAS Number: 183552-38-7
Sequence: Ac-D-2-Nal-D-4-Cl-Phe-D-3-Pal-Ser-N-Me-Tyr-D-Asn-Leu-Lys(ipr)-Pro-D-Ala-NH2
Molecular formula: C72H95ClN14O14
Molecular weight: 1416.06
Post time: 2025-08-20