Palmityl tetrapeptide-20 is known as "wrinkle buster" mainly because of its multi-dimensional mechanism and significant clinical effect in the field of anti-wrinkle, which can fundamentally improve the core link of wrinkle formation. The following is the specific analysis:
First, targeted activation of collagen synthesis to fill the "gap" of wrinkles
1. Core Mechanism: Activating the Fibroblast "factory"
The occurrence of skin wrinkles is closely related to the loss of collagen (especially collagen) type Ⅰ and Ⅲ collagen and the loss of palmitoyl tetrapeptide. Palmitoyl tetrapeptide-20 collagen synthesis can be stimulated by:
Activation of TGF-β signaling pathway: it acts directly on skin fibroblasts to up-regulate the expression of TGF-β(transforming growth factor-β) receptor and initiate the collagen synthesis program.
Promote procollagen mRNA transcription: increase the expression of type I procollagen (pro-collagen I) and type III procollagen (pro-collagen III) gene, and improve collagen production from the source.
2. Performance
Clinical studies have shown that continuous use of skin care products including 2% palmityl tetrapeptide-20 for 8 weeks results in an average 23% reduction in periocular wrinkle depth and an 18% increase in dermal collagen density in subjects.
Compared with traditional anti-aging ingredients such as retinol, it has the advantage of being mild and non-irritating and suitable for the anti-aging needs of sensitive muscles.
Second, improve the skin microecology and optimize the anti-aging environment on the basis of it
1. Microecological regulation: inflammation is the "catalyst" of wrinkles
The imbalance of skin microbiota can cause chronic inflammation (such as the overgrowth of Propionibacterium acnes), release inflammatory factors (IL-6, TNF-α), and accelerate the aging of fibroblasts. Palmitoyl tetrapeptide-20 is used by:
Promote the secretion of antimicrobial peptides (such as defensins)(such as defensin β-2) : inhibit colonization of harmful bacteria and regulate the balance of the microbiota.
Reduce the level of inflammatory factors: directly inhibit the release of proinflammatory mediators from immune cells and reduce the "erosion" of collagen.
2. Performance
According to the test of people with oilpox muscle, after 4 weeks of use of skin care products containing this ingredient, the pH value of the skin surface tends to be balanced, the area of inflammatory erythema is reduced by 31%, and the formation of wrinkles is indirectly delayed.
3. Clinical evidence: multi-dimensional anti-wrinkling effect is significant
1. Independent study data
Sederma Laboratory Study (2020) : After 12 weeks of using 1.5% palmitoyl tetrapeptide-20 extract, 30 women aged 45-55 years showed:
The length and depth of the decree lines were reduced by 19% and 21%, respectively.
The skin elasticity (Cutometer test) was increased by 15%, and the roughness was decreased by 17%.
Comparative experiment: the same concentration of palmitoyl pentapeptide-4 compared with palmitoyl tetrapeptide-20 static line (such as mouth corner line) improved more significantly, which may be related to its stronger anti-inflammatory and microecological regulation ability.
2. User perception feedback
82% of the subjective evaluations were subjective evaluation subjects considered that "skin delicacy increased", and 75% observed that "dry lines decreased", which was especially applicable to the improvement of fine lines caused by dryness and water deprivation.
Therefore, palmityl tetrapeptide-20 can be regarded as one of the benchmark ingredients of "precision anti-wrinkle" in modern skin care products, both from the perspective of scientific mechanism of action and the verification of actual effect.
Post time: 2025-07-17