α-MSH (11-13)/67727-97-3/Peptide purification

Description

α-MSH (11-13) is a fragment peptide of α-MSH, composed of the 11th to 13th amino acids in the α-MSH sequence. It exhibits significant anti-inflammatory and antipyretic effects in various animal models and is considered a potential drug for the treatment of inflammatory diseases.

Specifications

Apperance: White to off-white powder

Purity(HPLC): ≥98.0%

Single Impurity: ≤2.0%

Acetate Content(HPLC): 5.0%～12.0%

Water Content (Karl Fischer): ≤10.0%

Peptide Content: ≥80.0%

Packing and Shipping: Low temperature, vacuum packing, accurate to mg as required.

FAQ：

What length of peptide is appropriate?
Peptide synthesis needs to consider factors such as the length, charge, and hydrophilicity of the peptide. The longer the length, the purity and yield of the crude synthetic product decrease, and the difficulty of purification and the chance of non-synthesis will be greater. Of course, the sequence of the functional region of the polypeptide cannot be changed, but for the smooth synthesis of the polypeptide, sometimes some auxiliary amino acids have to be added to the upstream and downstream of the functional take to improve the solubility and hydrophilicity of the polypeptide. If the polypeptide is too short, there may also be problems with synthesis, the main problem is that the synthetic polypeptide has a certain difficulty in the post-processing process, and the polypeptide below 5 peptides generally has hydrophobic amino acids, otherwise the post-processing is more difficult. Peptides below 15 amino acid residues generally have satisfactory yields and yields.

What do I need to look for when designing phosphorylated peptides?

When designing phosphorylation modifications, the phosphorylation modifications should not be more than 10 amino acids away from the N-terminus to avoid a decrease in coupling efficiency.

What do I need to pay attention to when introducing fluorescent modifications into peptides?
It is recommended to add a linker between the peptide molecule and the fluorescent modification, which can reduce the effect of the fluorescent modification on the peptide folding and binding to the receptor. However, if the purpose of the fluorescence modification is to quantify the fluorescence migration between different structures, the introduction of a linker is not recommended.

What are the uses of peptides?

Peptides have a wide range of applications in the biomedical field, including:

Drug development: Peptides can be used as lead compounds for drugs or directly as drugs themselves.

Vaccines: Peptides can be used as antigens for vaccine preparation.

Biomaterials: Peptides can be used to construct biomaterials, such as scaffolds for tissue engineering.

Diagnostic reagents: Peptides can be used in the development of diagnostic reagents, such as those for detecting disease-related proteins.

Cosmetics: Certain peptides have moisturizing, anti-aging, and whitening effects and can be added to cosmetics.

How To Order?

1. Contact us directly by phone or email: +86-13735575465, sales1@gotopbio.com.

2. Order online. Please fill out the order online form.

3. Provide peptide name, CAS No. or sequence, purity and modification if required, quantity, etc. we will provide a quotation within 2 hours.

4. Order conformation by duly signed sales contract and NDA(non disclosure agreement) or confidential agreement.

5. We will continuously update the order progress in time.

6. Peptide delivery by DHL, Fedex or others, and HPLC, MS, COA will be provided along with the cargo.

7. Refund policy will be followed if any discrepancy of our quality or service.

8. After-sale service: If our clients have any questions about our peptide during experiment, please feel free to contact us and we will respond to it in a short time.

All products of the company are only used for scientific research purpose, it’s prohibited to be directly used by any individuals on human body.